16α-Hydroxysteroid Dehydrogenase of Rat Kidney
نویسندگان
چکیده
منابع مشابه
Regulation of 11 -hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol
Elise P. Gomez-Sanchez,1,2,4 Venkataseshu Ganjam,5 Yuan Jian Chen,5 Ying Liu,4 Ming Yi Zhou,4 Cigdem Toroslu,4 Damian G. Romero,2 Michael D. Hughson,3 Angela de Rodriguez,2 and Celso E. Gomez-Sanchez1,2,4 1Endocrine Section and Research Service, G. V. (Sonny) Montgomery Veterans Affairs Medical Center, 2Division of Endocrinology, and 3Department of Pathology, The University of Mississippi Medic...
متن کاملEffect of Eclipta prostrata on 11Beta-Hydroxysteroid Dehydrogenase in Rat Liver and Kidney
Eclipta prostrata (EP) is often prescribed in combination with glucocorticoid to treat glomerular nephritis, nephrotic syndrome, and IgA nephropathy in clinical practice of Traditional Chinese Medicine. Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in ra...
متن کاملEffect of Luteolin on 11Beta-Hydroxysteroid Dehydrogenase in Rat Liver and Kidney
11Beta-hydroxysteroid dehydrogenase (11β-HSD) enzymes control the glucocorticoid (GC) signaling, which is essential in regulating homeostasis. Our previous study revealed that Eclipta prostrata (EP) affected the activity and expression of 11β-HSD enzymes which might improve the efficacy and reduce the adverse drug effects of glucocorticoid in patients undergoing combinational therapy. However, ...
متن کاملModulation of 11β-hydroxysteroid dehydrogenase 1 by β2-adrenoceptor in the ischaemia-reperfused rat kidney.
BACKGROUND 11β-Hydroxysteroid dehydrogenase Type 1 (11βHSD-1) amplifies intracellular levels of active glucocorticoids which possess protective effects against organ ischaemia and reperfusion (I/R). However, the mechanisms by which 11βHSD-1 is modified after a renal I/R challenge remain unclear. This study investigated the effect of β(2)-adrenoceptor (β(2)-AR) activation and the subsequent sign...
متن کاملRegulation of 11 beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol.
The 11beta-hydroxysteroid dehydrogenase (11betaHSD) type 1 (11betaHSD1) enzyme is an NADP+-dependent oxidoreductase, usually reductase, of major glucocorticoids. The NAD+-dependent type 2 (11betaHSD2) enzyme is an oxidase that inactivates cortisol and corticosterone, conferring extrinsic specificity of the mineralocorticoid receptor for aldosterone. We reported that addition of a reducing agent...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1966
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)99804-2